Are you tired of cranking out the same old header-content-footer web layouts we see? Wonder if a WP page even needs a header, or a footer? Wanna get seriously crazy with page layout in WP?
I have two recommendations:
Make lots of thumbnail sketches. Then make some more.
Master the fine art of registering widget areas.
If you can register a set of widget areas, and load them up with graphics, type and images, you can make a WP page look like ANYTHING.
You can even make a phone screen look interesting!